Journal:
Proceedings of the International Conference on High Performance Computing, Networking, Storage and Analysis, SuperComputing. IEEE Press
Abstract:
Retroviruses are pathogens characterized by their ability to
incorporate viral DNA into a host cell’s genome. Retroviruses
like Rous Sarcoma Virus (RSV) infect cells during mitosis, when
the chromatin is exposed to the cytoplasm. Conversely, the genus
of lentiviruses, like the human immunodeficiency virus (HIV),
have evolved to infect non-dividing cells [1]. Despite infecting
cells at different stages of their life cycles, RSV and HIV share
a similar late stage replication cycle that is highly dependent
on the group actin polyprotein precursor (Gag), which contains
the matrix (MA), capsid (CA) and nucleocapsid (NC) proteins.
Both HIV’s CA and Gag are considered unexploited targets for
pharmaceutical intervention. We describe the techniques that
were used to build, simulate, analyze and visualize the structures
of both Gag and CA, and we discuss scientific visualization needs
that spurred development of an interactive GPU-accelerated ray
tracing engine and the use of remote visualization technologies.
Date:
2015
Journal link:
keywords:
Virology